Case studies

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Download the R scripts, Mlxtran and pharmML codes used for these case studies

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PKPD models and others…

• Step function
• Enterohepatic recirculation model
• Target-Mediated Drug Disposition (TMDD) Models

Clinical Trial Simulation

• Individualised therapies
• Comparing several dosage regimens – part I
• Comparing several dosage regimens – part II
• Comparing several dosage regimens – part III

Modelling & Simulation Workflow

We show how simulx can be easily integrated in a workflow: i) modeling is performed first with Monolix, ii) simulation is then performed with Simulx, using the parameters estimated by Monolix

• A PK example
• A PKPD example
• An example with continuous PK and categorical PD data
• An example with continuous PK and repeated events
• Two examples with censored data

Sensitivity analysis

• Sensitivity analysis for a PK model

Gene expression

• The Hog1-induced gene expression model

Tumor growth models

• Some tumor growth models
• Using tumor growth models from the DDMoRe repository