Simulx {mlxR}

Simulx
  • User Guide
  • Videos
  • Case studies
  • Simulx & Shiny
  • mlxR
  • Notes
  • Installation
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Case studies

Case studies


Download the R scripts, Mlxtran and pharmML codes used for these case studies


PKPD models and others…

  • Step function
  • Enterohepatic recirculation model
  • Target-Mediated Drug Disposition (TMDD) Models

Clinical Trial Simulation

  • Individualised therapies
  • Comparing several dosage regimens – part I
  • Comparing several dosage regimens – part II
  • Comparing several dosage regimens – part III

Modelling & Simulation Workflow

We show how simulx can be easily integrated in a workflow: i) modeling is performed first with Monolix, ii) simulation is then performed with Simulx, using the parameters estimated by Monolix

  • A PK example
  • A PKPD example
  • An example with continuous PK and categorical PD data
  • An example with continuous PK and repeated events
  • Two examples with censored data
  • An example with inter occasion variability

Sensitivity analysis

  • Sensitivity analysis for a PK model

Gene expression

  • The Hog1-induced gene expression model

Tumor growth models

  • Some tumor growth models
  • Using tumor growth models from the DDMoRe repository
Simulx is developed by the Inria Xpop team
Simulx is governed by the CeCILL-B license
Simulx requires the Lixoft simulation engine

Contact: marc.lavielle@inria.fr
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INRIA